The Mouse anti MUC1 (CD227) Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CA 15-3, CA15-3, CD227, KL-6, MAM6, MUC1, and Mucin 1. This antibody recognizes Human antigen. The Mouse anti MUC1 (CD227) Antibody has been validated for the following applications: Electron Microscopy, ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - frozen, Immunoprecipitation, and Western Blot.
Description
Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs.The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers